By Dave Workman The Portland, Oregon City Council is giving serious consideration to an ordinance which would ban licensed concealed carry in “certain city-owned buildings where official government meetings are held,” according to published reports, igniting a bristling reaction from Second Amendment advocates. KPTV News is reporting the proposal would remove the current exemption for […]
Federal Ammunition, Mossberg, and Palladyne AI have announced the launch of a joint development of SwarmShot a "purpose-built ammunition, an airborne weapon module". The new consortium plans for SwarmShot to first be developed as a modular mission add-on for Palladyne AI’s Gremlin-X Group 1 quadcopter mini-bomber with future plans to develop an integration kit for compatible third-party drones. The consortium's announcement explained:
Back in July Colt CZ Group announced that the Montenegrin Armed Forces had selected CZ small arms, ammunition and accessories. This included the new CZ Bren 3 as well as pistols, precision rifles and CZ Scorpion EVO 3 submachine guns. At the time Colt CZ Group's CEO, Radek Musil, said: "We are pleased to become a partner to another NATO member state in the process of modernization of its armed forces. We are also proud that CZ BREN 3 rifles will be newly adopted into the service of a NATO country."
Welcome back to Front Line Friday. This week is an editorial, and the topic is how agency procurement cycles produce gear that is already behind the curve by the time it hits the field, and why the officers holding that gear are right to be frustrated. Front Line Friday is brought to you by Dead Air Silencers , whose support keeps this column going every week.
I had an opportunity to put a few rounds through an M3M during a recent FN range day and the cyclic rate of 1,100 rounds per minute, twice that of the M2, is something to be experienced. The FN land and sea pintle mount is incredibly stable and the shoulder support helps rapidly traverse and elevate the gun. The recoil dampening mount means the operator feels almost none of the weapon systems recoil and keeps its sight picture through mounted optics stable. It also has an articulated charging handle which makes readying the weapon to fire much easier and (along with the mounts reduction of recoil) reduces operator fatigue.
This was the key figure in a Nature Medicine paper published on Dec 14, 2021. It showed clearly that myocarditis after vaccination (in this case, Moderna dose 2) was higher! than myocarditis after sars-cov-2 infection for people <40.
There were a few remaining issues. While the denominator for vaccines is known with precision, the true number of infections is unknown. Many people don’t seek testing or medical care. So the red bar above will be shorter if you used a sero-prevalence (aka the correct) denominator. The authors needed to fix this.
The other problem is that this analysis lumps together men & women, while men have the greatest risk. Well, the authors are back with a new pre-print to fix this point, and here is what they find.
It is now clear for men <40, dose 2 and dose 3 of Pfizer have more myocarditis than sars-cov-2 infection, and this is true for dose 1 and dose 2 of Moderna.
Pfizer boosters (Dose 3) have more myocarditis for men <40 than infection.
Myocarditis post infection is more common as you get older, in contrast with myocarditis post vaccination, which is more common as you are younger (reverse gradients).
HP LaserJet Enterprise printers ship with a self-signed certificate and no ACME client. Mine now serves a Let’s Encrypt certificate on its admin page and on IPPS/AirPrint, and a small Alpine container on Proxmox renews it every two months without me touching the printer. Here is how.
https://youtu.be/uTrQiArjn_I Designed by Augustin Nečas in 1954, the ZKP-541 is a .22 rimfire target pistol, also called the Universal Super Rapid. It is designed to use .22 short, and long rifle, with different bolt assemblies [...]
by Dean Weingarten in GUN WATCH on 2026-10-09T13:25:53Z
The 1879 Reichsrevolver was adopted by the German military a few years after German unification. Author attached a red dot optical sight without modifying the revolver. It is clamped on, with no metal removed. Ejector rods were separate. The one above is homemade.
Consider the pistol the revolvers were to replace, the Kavalleriepistol M 1850. It is about .59 caliber, firing a 267 grain round ball from a smooth bore, contained in a paper cartridge with about 67 grains of black powder.
Interpolating from data measured at the Youtube channel capandball, the 267 grain ball from the smoothbore was probably traveling about 650-700 fps. Accuracy was sufficient to hit man sized targets at 23 yards.
When the German empire was consolidated under Bismark, the new government realized they needed a standardized cartridge revolver. Germany officially started to work on the problem in 1871. They considered the Swiss double action design, a 10.4 rimfire adopted in 1872. The French 1873 is a very similar double action, with a weaker cartridge. They considered an Adams double action design from England, the Colt 1873, and others.
In 1873, the Germans ordered 40 Colt Single Action model 1873 revolvers in 10.6 x 25, the German knock off of the .44 Russian. The .44 Russian was being produced in Germany at the time, for the Russians and their Smith & Wesson single action, top break revolvers.
There was a miscommunication, and Colt sent 40 revolvers in .45 Colt. The Germans rejected them and sent them back. Colt, through their brokers in London, immediately sent another 40 in 10.6 German. Those revolvers were tested and sent to German regiments for a year of testing according to Heinrich E. Harder in "Der Reichsrevolver und seine Varianten". The early Colt 1873 revolvers had iron frames.
In 1877, the Germans decided to stop testing foreign revolvers and to create a design of their own. What resulted was the 1879 Reichsrevolver. It is a large, single action revolver. The grip, sights, size, length of barrel and lack of ejector rod are derived from the M 1850 muzzle loading percussion pistol. The lockwork is highly reminiscent of the Smith & Wesson single action. The cartridge is a German pattern .44 Russian.
The Germans selected a cartridge and built a revolver around it.
The commission which selected the 1879 has been criticized for selecting an obsolete design when double action revolvers such as the Swiss (converted to centerfire in 1878) was available in 1872. From reading online, the 1879, and particularly the upgraded 1883 were well received by the troops. They found them rugged and reliable. The Reichsrevolvers have a reputation for not breaking and always working. They go bang when you pull the trigger (after being cocked). Both Russia and the United States had selected single action revolvers for their armies a few years earlier.
The 1879 was a huge improvement over the muzzle-loading M 1850. Consider the advantages of keeping about the same size, the same sights, the same grip and single action. The troops already understood the necessity of cocking the pistol before shooting. They were used to the grip. They were used to the sights. The 1850 had a safety guarding the percussion cap. The 1879 had a safety guarding the primers of the cartridges. Even the Lanyard ring was the same.
In one handgun the German military man had six shots compared to two shots with two different pistols. The revolver was many times as accurate as the smooth bore single shot. It was more powerful with about the same bullet weight and half a pound lighter. The 1850 muzzle-loader had its ramrod attached to the ammunition pouch. The 1879 revolver had its ejector rod attached to the cartridge carrier, which was a modified ammunition pouch from the M 1850.
Group shot with optical sight 1879 Reichsrevolver, from a rest at 10 yards. Center to center, .784 inches, six shots. Handloads were well under .44 Russian maximum pressures, according to the loading manual. They produced 787 fps with a 240 grain cast bullet from the 7 inch barrel.
The iron sights of the 1879 are near duplicates of the sights on the M 1850. The 1879 has mechanical accuracy comparable to good modern revolvers with good ammunition.
The front sight of the 1879. It still has the cannon ring to protect the muzzle.
Here is the rear sight of the 1879. It is the same small v-notch as filed in the rear of the 1850.
The 1879 Reichsrevolver is a fine example of German craftsmanship. It fires a powerful and accurate cartridge. It is tough and reliable. It used real German steel when Colt was still using iron for their revolver frames. Colt switched to steel in 1883, according to Grok. The 1879 was quickly supplanted by a lighter version with a better grip and a 4 5/8 inch barrel, in 1883. Both Reichsrevolvers are reported to have had good reputations in the German military. The German Luger and the 9x19mm cartridge were officially adopted in 1908. The Reichsrevolvers served in the reserves and with second tier troops, reportedly into WWII. The 9x19 Luger cartridge became a world standard.
In the black powder era of 1879, the .44 Russian/10.6x25 German was a world standard. It was known as an extremely accurate cartridge. It paved the way, with its inside lubricated bullet, for most modern cartridges. In hindsight, the double action/single action revolver was the wave of the future. It did not seem so to the German Commission which selected a new handgun in 1879.
by Dean Weingarten in GUN WATCH on 2026-10-09T13:21:53Z
A man is dead after an early morning shooting in Baker County that investigators say appears to have been an act of self-defense.
According to the Baker County Sheriff’s Office, deputies responded around 4:30 a.m. Monday to the Macclenny Veterinary Hospital, where a 77-year-old woman reported shooting a man who attacked her.
Investigators said the woman, who has only been identified as the victim, shot 57-year-old Alvin Tyrone Tisdale. Tisdale was taken to UF Health Jacksonville, where he later died.
by Dean Weingarten in GUN WATCH on 2026-10-09T13:18:53Z
Priest described the tense encounter, "It unfolded quickly, but any reasonable person would definitely realize that their life is in danger. And of course, homeowner, wife, children in the house, so I mean he really, there wasn't really, I mean there was, I don't know of any options he could have used that wouldn't have, you know, potentially resulted in a more tragic situation than we already had."
The homeowner shot Edwards, who died at the scene. Police said Edwards had no connection to the second home.
Updated: 10/1/26 I taught my Sociology of Guns seminar at Wake Forest for ten years in a row, from 2015 to 2024. In year ten, I still enjoyed it but was not quite as excited as I was in year one. So, I took 2025 off. This fall I’m back teaching the course for the […]
Awoke this morning, got coffee started then walked outside to the patio to let the dawg get his morning constitutional. Chilly outside, almost brisk. Checked the thermometer, 57F. Clear skies, low humidity.
Florida and Alabama are bracing for what looks to be a major hurricane. This thing has shifted east enough that I expect no impact from it at all. That is fine with me. While I don't wish disaster on anyone, it is okay with me if hurricanes go somewhere else. I've lived through mine, some worse than others.
Belle has been out of town for the past two days helping her older brother. She is due back this afternoon, so the dawg and I have been batching it here on the acre. The dawg has not starved, but he is a bit concerned, wondering where she went. He will be quite excited when she pulls into the driveway. I can't say that I blame him.
A lever gun with M-LOK slots, a one-piece Picatinny rail and a suppressor-ready barrel is not what most people picture when they hear "lever action," but that is exactly what Savage Arms has built. The new REVEL Tactical joins the REVEL Classic and REVEL DLX as the third member of the series, and it keeps the smooth cycling of a lever action while adding the accessory-ready features modern shooters ask for.
Quote of the Day Armed Self-Defense Belongs in the Public Record The CDC’s correction does not establish an exact annual count or mean every defensive gun use saved a life. It does restore a fuller account of research on Americans … Continue reading →
New partnership brings together two leading boating organizations to advance safety education, strengthen collaboration with states and support America’s boaters.
The recent spate of cooler evenings had me thinking more and more about coffee-influenced cocktails to pair with my evening smoke. And then, as is often the case in Virginia, the temperature reversed direction. After a string of cool 60° evenings, we went right back to temperatures above 80° as the sun was setting.
That switch caused me to set aside my plans for an after-dinner Revolver, replacing it with a classic Bourbon Old Fashioned. I didn’t change my cigar plan, however. For the cool after-dinner smoke, I grabbed a Montecristo Espada Conquistador Ricasso. The cigar is part of the Espada family from the company formerly known as E.P. Carrillo, which was rebranded as Casa Carrillo in 2025. This particular addition to the Espada line was introduced in June 2026. I added some to the humidor only about six weeks ago, but figured that was enough rest time to light one up.
The box-pressed 5 x 50 Ascend Saddle features an Ecuadorian Habano wrapper over Nicaraguan binder and fillers. The cigar is made at the Casa Carrillo factory in Santiago, Dominican Republic. The Ascend lineup was introduced in mid-2026, and my cigars have had about six weeks of rest in the humidor.
The cigar opens with notes of cedar, roasted nuts, earth, and soft spice. There’s already a creamy sweetness to the smoke. As the cigar progresses, lightly roasted coffee notes join in. A bit of black pepper and cedar remain in the background, but neither is a major part of the profile. The cigar eventually moves into the medium-full-bodied realm, remaining well-balanced with good depth of flavor.
The Old Fashioned turned out to be an excellent accompaniment to the Ascend. The drink doesn’t overwhelm the cigar’s softer coffee notes, allowing the cedar, nuts, baking spice, and sweetness to stand out. The bourbon cocktail adds its own caramel and vanilla notes, but the pairing never strays into overly sweet territory. The bourbon’s oak and vanilla also seem to reinforce some of the cigar’s own woody and sweet notes, while the expressed orange provides a bit of brightness that keeps the combination from becoming too heavy.
I particularly liked the way the two worked together without either one dominating. The Ascend has enough flavor and body to stand up to the bourbon, while the Old Fashioned provides just enough sweetness and contrast to complement the cigar’s richer notes. It was a fairly straightforward pairing, but sometimes that’s exactly what you’re looking for.
The Casa Carrillo Ascend Saddle was a fairly quick smoke, just around 45 minutes. The short-and-sweet pairing was rich but not heavy. Just the thing for a warm autumn evening repast.
The return of 80° evenings was a reminder that Virginia wasn’t quite ready to let go of summer yet. But that’s OK. There’s a good cigar and drink pairing for just about any weather.
Built for shooters who appreciate classic craftsmanship with modern performance, the Akkar USA Open Country Series delivers reliability, versatility, and timeless style in every shot.
Knowledge to make your life better. If you have some free time, check out some of these links this weekend. Run It Like A Violin – Shotgun Reloads Until a couple years ago, I was at best ambivalent towards the violin load. I knew some people used it successfully, but I did not teach […]
A correspondent recently shared this statement by Murray Rothbard with us. This is not just true, but in recent decades since Murray passed on, the evidence of its truth has grown. Perhaps exponentially. As followers of the Creator, we hasten … Continue reading →
The M4A1 is one of the most recognizable U.S. military carbines of the modern era. Still, the weapon that entered service in the 1990s is not quite the same M4A1 that soldiers and special operations forces use today. Its development has been driven by a recurring problem: how to keep the M4's compact size while making it withstand the much higher firing schedules of combat and intensive training.
Photo Of The Day: Exercise Crete, held at Waiouru Military Training Area and led by 1st Battalion, Royal New Zealand Infantry Regiment, stood as one of the largest NZ Army exercises in 2025, culminating in a live-fire defensive battle at dawn on the final day. More than 300 personnel participated, including infantry, armour, artillery, engineers, and supporting elements. The exercise served as a tactical milestone following 1RNZIR's December 2025 amalgamation with Queen Alexandra's Mounted Rifles.
Welcome to another edition of Concealed Carry Corner . Last week, we looked at why the Glock 19 became the gold standard in the concealed carry market. If you happened to miss that article, be sure to click the link here to check it out. This week, I want to take a look at some of the biggest mistakes people make when training and how to bridge the gap between the drills you shoot at the range and carrying your concealed handgun every day. Let's take a closer look at how it can be beneficial to build skills at the range.
I never saw this feature coming, but it’s here and it will make sense to a lot of people. SIG Sauer has built a weapon light that talks to an optic. The FOXTROT2R LightFight is a 700-lumen, 20,000-candela white light with one party trick: it is "Connected by LIGHTFIGHT”, a Bluetooth link between the light and SIG Sauer’s new XRAY5 red dot.
Dark matter outweighs everything astronomers can see, and nobody has ever held a piece of it. Daniel Defense is aiming for something similar with Gray Matter, a dealer-exclusive run of the DDM4 V7 SLW finished in gray from end to end. It is available now; it comes only through Daniel Defense dealers, and "Once it's gone, it's gone."
Amazon has a tremendous number of FREE ebooks on their website. You can find thousands of free kindle books on Amazon’s site every day. These books can be downloaded to a Kindle reader or a free App on your phone or personal computer. Even if you don’t have a Kindle, you can download a free […]
by Clayton Cramer in Clayton Cramer. on 2026-10-08T15:36:31Z
Medicare in Idaho cost both the several hundred dollar Medicare premium deducted from my Social Security check, but also an additional $89 owed directly to Blue Cross of Idaho to cover what my Medicare Advantage added beyond Medicare: dental, vision, and some4 additional prescription coverage. In Tennessee, Blue Cross covers everything for the premium from my Social Security check alone. We signed up for the Diamond plan: $0 copayments for PCP; $20 copayment for specialists.
SIG Sauer has made the laser rangefinder smaller than it has ever been. The KILO MICRO 4x18mm monocular weighs just 3.4 ounces (96 g) and measures 2.7 by 1.2 by 1.9 inches. "Built to go anywhere" is the slogan, and whatever fits my pocket is always welcome on the tour. The KILO MICRO uses GEN II Lightwave DSP, which delivers fast, accurate ranging with extreme short-range resolution. It reaches reflective targets out to 1,000 yards, trees out to 800 yards and deer out to 600 yards. The laser divergence is 2.6 by 1.2 MRAD.
As Thursday morning begins, all the weather watchers are focused on that unpronounceable storm in the Gulf. It's coming ashore tomorrow, that is for sure, the question is where it will make landfall. Current models put it making landfall at Pensacola, but that is subject to change.
The other question is how much of the SEC is it going to disrupt? Will it take out Georgia at Alabama, will it disrupt LSU at Kentucky? The big question is timing. And power outages. There are plenty of smaller schools in the path of the storm and many of them have games scheduled in lesser conferences.
The weather falls on everyone equally. The rich and the poor, the strong and the feeble. It simply seems to hurt the poor and feeble more often. If I lived in Mobile or Pensacola, I would be considering a weekend trip. Somewhere west and away from the coast.
by Dean Weingarten in GUN WATCH on 2026-10-08T13:56:48Z
After leaving the SUV on the railroad tracks, the suspect walked to Dixie Road, where he approached a passing motorist and allegedly attempted to enter the vehicle and take it from the driver.
The motorist, a Rankin County resident who owns and operates a firearms store and firearms training facility in Flowood, feared for his safety and produced a firearm. The citizen held the suspect at gunpoint until Rankin County deputies arrived and took him into custody without further incident.
by Dean Weingarten in GUN WATCH on 2026-10-08T13:54:19Z
Investigators determined Bumcon and Deangelo Robinson had allegedly been following a man while he was making Uber deliveries. Police said the victim tried to get away before reaching a dead-end road, where Bumcon and Robinson began firing at his vehicle.
Police said the victim returned fire as the encounter continued. More than 60 rounds were fired in total.
I've been low-key chasing one of these for some time.
The full-size five-inch Smith & Wesson Model 1026 is one of the rarer 10mm Third Gen autos, with a little over 3,100 pistols manufactured over a two year run. Only the DAO Model 1046 and Model 1086 are less common.
Over two thirds of those went to the Virginia State Police. This one's got the "CAUTION: Capable of Firing With Magazine Removed" legend on the slide, so it was likely sold to an LE agency.
It also has the punch mark on the bottom of the grip showing it has the upgraded grips that won't break when dropped like the early Xenoy units, as well as the two punch marks under the decocker lever showing it had been back to Springfield for the upgraded lockwork.
This week I'm joined by Jacob Albaugh and Mike Herne of TENET, the Dayton, Ohio company building direct-thread titanium suppressors, around one question: why should a hunter have to choose between a muzzle brake and a can? Jacob got into the industry by way of a hard-kicking .30-06 and a welder, and that path led to a prototype that posted the lowest average sound reading of more than 100 suppressors in Outdoor Life's suppressor and brake test. We get into that test, the HORIZON brake system, and the production version of that prototype, the new VESPER series .
We recently lost Evan Marshall, a valued friend and a famous cop. Evan Marshall was a strong and early voice in the officer survival training movement, and is believed to have originated the term “street survival.” He passed a few days before his 84th birthday.Evan’s solid advice in gun magazines and law enforcement professional journals […]
For this month’s installment of Gal Gab, we travel north to Ontario to find out what TV personality and avid hunter Amanda Lynn Mayhew has to say about the outdoor industry … and, how she’d go to battle with a giant.
Quote of the Day Americans traveling to visit family, work, or take a vacation have the same right to protect themselves that they have at home. The Denver lawsuit seeks to restore that freedom for Hoffman and others in his … Continue reading →
So they sent me for a PET scan, to see if the cancer had spread. It hadn't. Nice.
A PET scan is kind of like an MRI, but first they inject a die that gets absorbed by cancer tumors. A radioactive die. It came encased in a big lead shield. I thought they're going to inject that into me? Yup.
I also got the first of the hormone injections. It wasn't bad, and the only real side effects have been fatigue. The Lupron starts at the end of the month; that's where I expect side effects.
They're scheduling a spacer, which is a gel injected next to the prostate. It will let them be more accurate with the Death Ray beam, keeping it focused on the lesions and not zapping parts of me I want to keep. Radiation will be every day starting in 2 or 3 weeks and will go probably until the end of the year.
All in all, not as fun as a barrel of monkeys but not so bad so far.
By Dave Workman The smoke hasn’t quite yet cleared in Seattle more than two months after a deadly shooting on the final day of the annual “Bite of Seattle” food fest, and socialist Democrat Mayor Katie Wilson increasingly appears to be sailing a rudderless ship with not many oars in the water. A report in […]
by Clayton Cramer in Clayton Cramer. on 2026-10-08T02:21:52Z
I have been so busy unpacking telescopes and shop that I have not taken a serious look at my night sky.
I have the mount for the Televue-85 on the back porch which is so dark that I absolutely will need my little red LED headlamp to avoid injuries. It is dark there at a level at which the last two houses could only hint. To my pleasure, not only are the third magnitude stars of Lyra visible, they do not require averted vision to see them. While not at the level of my house in the hills north of Boise, the Milky Way is visible above me. The area by the shop of which where the telescopes will roll once I have a pad poured is likely even darker.
I am too tired right now but tomorrow night I will start setting up about 8:30. Being closer to the equator, the Sun sets much faster and the sky gets dark much more dramatically.
No doubt you will have seen at least some of these online (or if you are old enough, in a magazine or newspaper, hah!). Think about liberty, promoting liberty, learning to live free, and teaching others have to live free! … Continue reading →
A routine family visit turned into the kind of firearm discovery most shooters will never experience. When my buddy ducked into the guest room to check on his kids, he certainly wasn’t looking for anything exciting.
We’ve told you - Germany's army is swapping rifles, one unit and one shooting range at a time. This is TFB's Photo of the Day and here we have soldiers of the 1st Company, Panzerpionierbataillon 701, based in Gera (Germany) that are getting acquainted with their future service rifle well ahead of their own unit's scheduled fielding date.
Finely embellished handguns are a thing of the past, right? Nobody goes in for engraving and other fancy-pants finishes anymore, right? Wrong. Uh, sort of. The Korth Dreadnought is an example of an old idea reborn for the 2020s, although it is a far cry from the work that F.W. Martin used to do at Smith & Wesson .
By Dave Workman Published reports have revealed that the billionaire-backed Everytown for Gun Safety gun prohibition lobbying group is “teaming up with House Democrats on a $10 million ad campaign” to support gun control advocates now running for Congress. Axios is identifying these candidates as “former volunteers for Moms Demand Action,” a subsidiary of Everytown. […]
President Donald Trump’s remarks about the possibility that Iran could “take out” Los Angeles and San Diego have sparked a firestorm of criticism, with Democrats claiming the president was either calling for a foreign adversary to attack the U.S. or portraying the destruction of two major cities as acceptable collateral damage.
But given the full context — as well as Trump’s numerous past comments on this issue and the White House’s later clarification — that’s not our reading of the president’s comments. While his wording is confusing, a more plausible interpretation is that he meant the war would prevent Iran from posing a threat to U.S. cities, and higher gas prices are a small sacrifice to make. He’s made versions of those points before, using similar language.
Trump’s remarks came during an Oct. 5 rally in Nebraska.
“Remember, with the war, it’s just artificial. It’s a little bit high,” he said, apparently referencing gas prices. “It’s a small price to pay for keeping the world safe, keeping our country safe. They could take out a city. Let them take — let it — let them take out Los Angeles. Let them take out San Diego.
“That’s — this is a very small price to pay, and it’s going to be over with very soon,” he continued. “It’s essentially almost over with.”
by Clayton Cramer in Clayton Cramer. on 2026-10-07T19:43:37Z
Dear Clayton,
Thank you for helping us make discoveries together.
Working with researchers at Dana-Farber Cancer Institute, we found that people carrying a rare inherited genetic variant called EGFR T790M had roughly 25 times higher odds of developing lung cancer. That is equal to or higher than well-established inherited cancer risk variants such as those in the BRCA1 and BRCA2 genes for breast and ovarian cancer.
These findings were recently published in the journal Science, in a peer-reviewed study titled 'Germline EGFR T790M mutation and lung cancer risk.' You can read the paper here.
Many people believe exposure to tobacco smoke is the only risk factor for lung cancer, but tens of thousands of Americans without this risk factor are diagnosed each year. For many people the question of why has had no good answer. This study is a step toward one.
What we discovered together:
• Researchers identified EGFR T790M as the largest known single genetic risk factor for lung cancer. This could have important implications for genetic testing and future lung cancer screening strategies for people who carry the variant.
• More common than anyone knew. Among more than 10 million research participants, 641 carried the variant. It remains rare, but that is about ten times more common than public genetic databases had reported.
• Specific to lung cancer. Often genetic variants that dramatically increase the risk of one cancer also increase the risk of other cancers, but for people with the EGFR T790M variant there were no significant associations with other frequent cancers, such as breast, prostate or colorectal cancer. This finding could help people with this variant know the specific, targeted screening they may need.
• A window into American history. By combining genetics with ancestry and geography, our researchers traced the variant to British and Irish settlers who migrated to the Southeastern United States. Regional expansion and demographic isolation led to a founder effect, where a small group is genetically separated from a larger population, in the Southern Appalachian region, making the variant far more common among their descendants. Participants with Southern U.S. ancestry were about six times more likely to carry this variant. This is a striking example of how our ancestors' origins can remain relevant to our health generations later.
Data analyzed in the study includes participants in the Lung Cancer Genetics Study, which is funded by the Susan Wojcicki Foundation and powered by the 23andMe Research Institute in collaboration with 22 lung cancer advocacy organizations. To learn more about the study, our collaborators, and eligibility criteria, visit the study landing page.
This kind of research is only possible at scale. By answering our research surveys, you help make discoveries like this possible. On behalf of the 23andMe Research Institute, thank you for being part of this journey.
For those of you who are local to Missoula: CostCo has the AA 25 qt pressure canner marked down to $199.97 with the ‘death star’ on the price label. Sez Google: The Costco “Death Star” is a small asterisk symbol … Continue reading →
by Clayton Cramer in Clayton Cramer. on 2026-10-07T18:43:15Z
It is about 200-250 feet from my router to the end of shop with the CNC mill. As you might expect, signal strength was not great. This TP-Link BE2000 WiFi extender did the job:
I was only getting about 850 Mbps in my office but with the extender in my wife's office (optimal for the shop) even my PC in my office is doing pretty well.
The basic idea of the Uxbridge Arms G6 is simple: Sometimes, people want a shotgun accessory to add to their rifle, typically for the purpose of door breaching (which is why they call them masterkeys). See Nick’s review of one such setup here , and there are plenty of others if you look around.
by Clayton Cramer in Clayton Cramer. on 2026-10-07T17:41:26Z
We replaced the corded pool cleaning robot named Poseidon that Lillie chased around the pool while chewing on its cord with a cordless version that being newer and more sophisticated is the Roman god of the sea: Neptune. Same dumb behavior.
3D printing has now reached production handguns, and up to 30% less muzzle rise is the headline promise behind the P365-MACH3D. This is a micro-compact 9mm that SIG Sauer pitches with the line "Peak Performance. Everyday Carry."
EOTech as a company was formed in 1995 as a spinoff of the University of Michigan Ann Arbor’s Environmental Research Lab, specifically to commercialize holographic weapon sights. Their first product was the Model 400, released [...]
NASA-supported human-factors research is not the usual starting point for a pistol grip, but it is where CZ's DiFEND methodology comes from, and it shaped the way the new CZ DUTY fits the hand. The rest of the pistol is just as deliberate. A serialized modular chassis holds everything together, a refined striker-fired trigger sits inside it, and the controls work for left- and right-handed shooters alike. The slide takes a red dot directly, with no adapter plates needed for four popular footprints. The CZ DUTY 4.0 lineup comes in four versions, with 15 or 17 rounds and with or without a manual safety.
Quote of the Day Under President Trump and Defense Secretary Pete Hegseth, the policy of lies that empowered the terrorist Hasan is being purged from our government, our military and our immigration policy. But those same lies are still told … Continue reading →
Most colleges and universities have a group or committee that act as quasi-judicial bodies under Title IX. They have taken Title IX and have perverted it to mean that they should create kangaroo courts without the safeguards of our actual judicial system (like innocent before being PROVEN guilty and, most importantly, allowing a person to […]
Yesterday while posting, I blindly asked Copilot what the next storm name might be, and it told me Cristobal. Imagine my surprise when I awakened this morning and find that the tropical depression has been named Isaias. So much for AI, I suppose. I need todo better research.
At any rate, we have another named storm, and this one is predicted to become a hurricane. Which means we have a cone.
That is an interesting cone, if only for the prediction that it is headed for the Gret Lakes. It appears that this one is headed for the Mississippi coast, but as always this is subject to change.
It was pretty cool to get a bit of the barrel-cylinder gap flash on this shot, especially because I wasn't shooting in burst mode. I had the Canon EOS R5 & RF 70-200mm f/4L IS in single shot mode and was just pressing the shutter release when the vibes felt right.
Barrel-life specifications are a familiar sight in government solicitations, technical documents, and manufacturer literature, but what do they actually mean? A barrel rated for a certain number of rounds is not necessarily guaranteed to perform identically throughout that entire service life, and the terminology can be easy to misunderstand. With different definitions, testing methods, and performance standards involved, “barrel life” is often more nuanced than a single round count might suggest. I’ve seen plenty of confusion surrounding the subject, so this quick overview will break down what barrel-life figures represent, how they are established, and what they do, and don’t, tell you about a barrel’s expected service life.
Weapons familiarization exists for exactly this moment: handing a soldier an unfamiliar rifle and letting muscle memory catch up. At Bemowo Piskie Training Area, Poland, a U.S. Army staff sergeant with 2nd Battalion, 3rd Field Artillery Regiment, part of NATO's Forward Land Forces Battle Group-Poland, fired a karabinek szturmowy wzor 96 "Beryl," Poland's standard-issue rifle since the late 1990s and a modernized descendant of the Kalashnikov pattern, built to run on the same 5.56x45mm NATO round as the M4.
Galco has rolled out the Combat Master 2.0, an updated take on its long-running Combat Master pancake belt holster, and the lineup now includes a fit for the Glock 17.
Knowledge to make your life better. If you have some free time, check out some of these links this weekend. Run It Like A Violin – Shotgun Reloads Until a couple years ago, I was at best ambivalent towards the violin load. I knew some people used it successfully, but I did not teach […]
Amazon has a tremendous number of FREE ebooks on their website. You can find thousands of free kindle books on Amazon’s site every day. These books can be downloaded to a Kindle reader or a free App on your phone or personal computer. Even if you don’t have a Kindle, you can download a free […]
Mix an AR and an AK together and what do you get? Grand Power ARAQ.
We recently lost Evan Marshall, a valued friend and a famous cop. Evan Marshall was a strong and early voice in the officer survival training movement, and is believed to have originated the term “street survival.” He passed a few days before his 84th birthday.Evan’s solid advice in gun magazines and law enforcement professional journals […]
Affordable, proven, and now massively upgraded. Canik Prime Radian is a must-try.
